— Feria III Majoris Hebdomadae — Statio ad S. Priscam —

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It is devoted to Saint Prisca, a 1st-century martyr, whose relics are contained in the altar in the crypt. It was built in the 4th or 5th century over a temple of Mithras. Damaged in the Norman Sack of Rome, the church was restored several times. The current aspect is due to the 1660 restoration, which included a new facade by Carlo Lombardi. In the interior, the columns are the only visible remains of the ancient church.

Also a baptismal font is conserved that by tradition was used by Saint Peter. The frescoes in the crypt, where an altar contains the relics of Saint Prisca, are by Antonio Tempesta. Anastasio Fontebuoni frescoed the walls of the nave with Saints and angels with the instruments of passion. In the sacristy hangs a painting of the Immaculate conception with angels by Giovanni Odazzi, and on the main altar a Baptism of Santa Prisca by Domenico Passignano.